Community-based programme improves depression in chronic pain patients

A community-based pain management programme for patients with chronic musculoskeletal pain has improved depression and social integration, according to a study led by Prof Stephanie Taylor from the Centre for Primary Care and Public Health, Blizard Institute at Queen Mary University of London (QMUL).

The researchers, in collaboration with Warwick University, Royal Holloway and University College London, designed a group pain management programme on 403 adults and compared this intervention with a control group of 300 adults who received usual care and a relaxation CD.

Trial participants all had chronic musculoskeletal pain, which often does not respond well to drugs. The pain management programme that was investigated is a novel, brief, psychologically based group intervention directed at increasing participants’ confidence and their repertoire of skills around managing pain.

The majority of participants in the intervention group reported feelings of depression and social integration had improved at six and 12 months on; and a cost-effectiveness analysis showed that the cost of this intervention (£145 per person) falls within the range defined as acceptable by the UK’s National Institute for Health and Care Excellence (NICE).

Professor Stephanie Taylor from QMUL’s Blizard Institute said: “The study holds out the tantalising prospect that the new intervention could improve the psychological well-being of patients with chronic musculoskeletal pain, but further research is needed before this conclusion can be firmly drawn.”

The researchers also looked at effects on anxiety, pain-related self-efficacy, pain acceptance and pain intensity at 12 months. However there was no reported effect by participants in the intervention group.

Pain-management programmes can be effective at reducing distress and improving self-efficacy and quality of life. However, when based in hospitals they can be expensive and it is hard to apply them to large numbers of people.

Research paper

Taylor SJC, Carnes D, Homer K, Kahan BC, Hounsome N, Eldridge S, et al. (2016) Novel Three-Day, Community-Based, Nonpharmacological Group Intervention for Chronic Musculoskeletal Pain (COPERS): A Randomised Clinical Trial. PLoS Med 13(6): e1002040. doi:10.1371/journal.pmed.1002040

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Barts and the London School of Medicine and Dentistry climbs to 2nd for medicine and 3rd for dentistry in the 2017 Guardian University League Table

Queen Mary University of London has been ranked the 34th best university in the UK by The Guardian University Guide 2017.

CLICK HERE to be taken to full Guardian 2017 league table.

The second place ranking represents a climb of two places from joint fourth in the 2016 league table.

In February 2015 an initiative was started in the Blizard Institute to recognise outstanding publications by our researchers. Each month, a shortlist is prepared by Prof David Kelsell, Deputy Director for Research, and Prof Graham Hitman, Institute Director, and sent out for all Blizard Institute staff and students to vote on. The winning publication becomes the Blizard Paper of the Month and at the end of the calendar year these are in turn entered into an open vote for Blizard Paper of the Year.

The results are in and in this our inaugural year we have two joint winners of Paper of the Year 2015:

The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans.

Lowe R, Overhoff MG, Ramagopalan SV, Garbe JC, Koh J, Stampfer MR, Beach DH, Rakyan VK, Bishop CL.   

Genome Biol. 2015 Sep 17;16(1):194. doi: 10.1186/s13059-015-0748-4.  PMID: 26381124 

Suppression of TGFβ and Angiogenesis by Type VII Collagen in Cutaneous SCC.

Martins VL, Caley MP, Moore K, Szentpetery Z, Marsh ST, Murrell DF, Kim MH, Avari M, McGrath JA, Cerio R, Kivisaari A, Kähäri VM, Hodivala-Dilke K, Brennan CH, Chen M, Marshall JF, O'Toole EA.

J Natl Cancer Inst. 2015 Oct 16;. Print 2016 Jan. PMID: 26476432     

The announcement was made at the Blizard Club Seminar on the 24th February - CONGRATULATIONS to Dr Rob Lowe and Dr Cleo Bishop and team and to Dr Matthew Caley and Prof Edel O'Toole and team:

 

The winners of the Paper of the Month Category for 2015 are listed below:

December 2015

Sofosbuvir and Velpatasvir for HCV Genotype 2 and 3 Infection.

Foster GR, Afdhal N, Roberts SK, Bräu N, Gane EJ, Pianko S, Lawitz E, Thompson A, Shiffman ML, Cooper C, Towner WJ, Conway B, Ruane P, Bourlière M, Asselah T, Berg T, Zeuzem S, Rosenberg W, Agarwal K, Stedman CA, Mo H, Dvory-Sobol H, Han L, Wang J, McNally J, Osinusi A, Brainard DM, McHutchison JG, Mazzotta F, Tran TT, Gordon SC, Patel K, Reau N, Mangia A, Sulkowski M; ASTRAL-2 Investigators; ASTRAL-3 Investigators.

N Engl J Med. 2015 Dec 31 Epub 2015 Nov 17. PMID: 26575258    

November 2015:

Bifidobacterium breve BBG-001 in very preterm infants: a randomised controlled phase 3 trial.

Costeloe K, Hardy P, Juszczak E, Wilks M, Millar MR; Probiotics in Preterm Infants Study Collaborative Group.

Lancet. 2015 Nov 25. pii: S0140-6736(15)01027-2. doi: 10.1016/S0140-6736(15)01027-2.   PMID: 26628328  

October 2015:

Suppression of TGFβ and Angiogenesis by Type VII Collagen in Cutaneous SCC.

Martins VL, Caley MP, Moore K, Szentpetery Z, Marsh ST, Murrell DF, Kim MH, Avari M, McGrath JA, Cerio R, Kivisaari A, Kähäri VM, Hodivala-Dilke K, Brennan CH, Chen M, Marshall JF, O'Toole EA.

J Natl Cancer Inst. 2015 Oct 16;. Print 2016 Jan. PMID: 26476432     

September 2015

The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans.

Lowe R, Overhoff MG, Ramagopalan SV, Garbe JC, Koh J, Stampfer MR, Beach DH, Rakyan VK, Bishop CL.   

Genome Biol. 2015 Sep 17;16(1):194. doi: 10.1186/s13059-015-0748-4.  PMID: 26381124 

August 2015

Percutaneous tibial nerve stimulation versus sham electrical stimulation for the treatment of faecal incontinence in adults (CONFIDeNT): a double-blind, multicentre, pragmatic, parallel-group, randomised controlled trial.

Knowles CH, Horrocks EJ, Bremner SA, Stevens N, Norton C, O'Connell PR, Eldridge S; CONFIDeNT study group.

Lancet. 2015 Aug 17. pii: S0140-6736(15)60314-2. doi: 10.1016/S0140-6736(15)60314-2.

July 2015

Azathioprine therapy selectively ablates human Vδ2+ T cells in Crohn's disease

McCarthy NEHedin CR, Sanders TJAmon PHoti IAyada IBaji VGiles EMWildemann MBashir ZWhelan KSanderson ILindsay JOStagg AJ.

J Clin Invest. 2015 Aug 3;125(8):3215-25. doi: 10.1172/JCI80840. Epub 2015 Jul 13.

June 2015

Double-blind randomised controlled trial of vitamin D3 supplementation for the prevention of acute respiratory infection in older adults and their carers (ViDiFlu).                                                                

Martineau AR, Hanifa Y, Witt KD, Barnes NC, Hooper RL, Patel M, Stevens N, Enayat Z, Balayah Z, Syed A, Knight A, Jolliffe DA, Greiller CL, McLaughlin D, Venton TR, Rowe M, Timms PM, Clark D, Sadique Z, Eldridge SM, Griffiths CJ.

Thorax. 2015 Jun 10. pii: thoraxjnl-2015-206996. doi: 10.1136/thoraxjnl-2015-206996.                                

May 2015

Triallelic and epigenetic-like inheritance in human disorders of telomerase.

Collopy LC, Walne AJ, Cardoso S, de la Fuente J, Mohamed M, Toriello H, Tamary H, Ling AJ, Lloyd T, Kassam R, Tummala H, Vulliamy TJ, Dokal I.

Blood. 2015 May 29. pii: blood-2015-03-633388. [Epub ahead of print] 

April 2015

Poly(A)-specific ribonuclease deficiency impacts telomere biology and causes dyskeratosis congenita.

Tummala H, Walne A, Collopy L, Cardoso S, de la Fuente J, Lawson S, Powell J, Cooper N, Foster A, Mohammed S, Plagnol V, Vulliamy T, Dokal I.

J Clin Invest. 2015 May;125(5):2151-60. doi: 10.1172/JCI78963. Epub 2015 Apr 20.       PMID:  25893599

May 2015

Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation.

Burguillos MA, Svensson M, Schulte T, Boza-Serrano A, Garcia-Quintanilla A, Kavanagh E, Santiago M, Viceconte N, Oliva-Martin MJ, Osman AM, Salomonsson E, Amar L, Persson A, Blomgren K, Achour A, Englund E, Leffler H, Venero JL, Joseph B, Deierborg T.

Cell Rep. 2015 Mar 4. pii: S2211-1247(15)00140-0. doi: 10.1016/j.celrep.2015.02.012. PMID:  25753426

February 2015:

Loss-of-function mutations in CAST cause peeling skin, leukonychia, acral punctate keratoses, cheilitis, and knuckle pads.

Lin Z, Zhao J, Nitoiu D, Scott CA, Plagnol V, Smith FJ, Wilson NJ, Cole C, Schwartz ME, McLean WH, Wang H, Feng C, Duo L, Zhou EY, Ren Y, Dai L, Chen Y, Zhang J, Xu X, O'Toole EA, Kelsell DP, Yang Y.

Am J Hum Genet. Feb 11.