The causes of cardiovascular disease are diverse, but during the last decade, the importance of mechanical factors in their pathogenesis has become widely recognised. For instance, changing stiffness of the large arteries is a powerful prognostic indicator of mortality and morbidity for hypertension, stroke and coronary heart disease. Our research activities are aimed at a better understanding of the relationship between arterial composition, structure and mechanical function and range from mathematical modelling of the shear waves resulting from disturbed blood flow, through investigation of impaired vascular function in patients with diabetes and thalassaemia, to understanding how fatigue failure of elastin in adult life contributes to hypertension associated with impaired growth in-utero. On the applied side, recent work has been concerned with the development of novel methods for the measurement of arterial function including the activity of matrix metallo proteases, investigating the haemodynamic properties of novel stent/grafts and the non-invasive and indeed non-contact measurement of arterial stiffness. These ideas are propagated to students undertaking the intercalated degree in experimental pathology for whom we provide all the teaching in the CV Pathophysiology module.