Kristin Braun

Kristin M Braun

Title: Dr
BA, PhD
Non-Clinical Lecturer in Epithelial Biology

Research in my laboratory aims to characterise genetic and epigenetic regulation of epithelial stem cells during tissue homeostasis, and evaluate how these mechanisms become deregulated during wound healing and disease pathogenesis.  We use mammalian epithelium to investigate these questions, including human tissue samples, genetically modified mice, and reconstitution of epithelia in cell culture.  Specific areas of investigation include:

  • Assessing the effects of Polycomb group repressors in regulating epidermal stem cells
  • Evaluating responses of epithelial cells to acute bacterial infection
  • Developing novel in vitro models of wound-healing

My contributions to undergraduate and postgraduate education have encompassed programme development, course/module leadership, facilitating assessment, project supervision and providing pastoral support.

Bio

Kristin Braun was awarded a PhD in Cellular and Molecular Biology in 2000 from the University of Wisconsin-Madison.  I then moved to the United Kingdom, training as a postdoctoral fellow in the Keratinocyte Laboratory at Cancer Research UK, where I developed a research interest in characterizing the epidermal stem cell compartment.  My postdoctoral training was supported by fellowships from the Imperial Cancer Research Fund and American Cancer Society.  In 2006, I was awarded an MRC Collaborative Career Development Fellowship in Stem Cell Research and appointed as a Non-clinical Lecturer in the Blizard Institute.   

 

Research

Recent and Ongoing Research Projects:

2014 - 2018 Primary Supervisor, BBSRC CASE PhD Studentship
Development of an organotypic co-culture model to assess oral wound-healing
 
2013 - 2014 Principal Investigator, Barts and The London Charity - Cancer Research Fund
Investigating pathological consequences of Chlamydia trachomatis infection as potential mediators of cervical neoplasia
 
2010 - 2014 Co-Supervisor, BBSRC CASE PhD Studentship. Lead:  Edel O’Toole
The role of basement membrane type VII collagen in aberrant differentiation and cell fate determination in ageing skin
 
2011 - 2013 Principal Investigator, British Skin Foundation - Project Grant
Assessing a putative epigenetic regulator of epidermal homeostasis and wound healing

Group Members

Mr. Christopher Smith, PhD student

Publications

Chikh, A., Matin, R.N., Senatore, V., Hufbauer, M., Lavery, D., Raimondi, C., Ostano, P., Mello-Grand, M., Ghimenti, C., Bhata, A., Khalaf, S., Akgul, B., Braun K.M., Chiorino, G., Philpott, M.P., Harwood, C.A. and Bergamaschi, D.  iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia.  2011.  EMBO J.  30(20) 4261-73.

Nijhof, J.G.W.*, Braun, K.M.*, Giangreco, A., van Pelt, C., Kawamoto, H., Boyd, R.L., Willemze, R., Mullenders, L.H.F., Watt, F.M, de Gruijl, F.R. and van Ewijk, W.  The cell surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells.  2006.  Development.  133(15), 3027-3037. (*Equal contribution authorship)

Silva-Vargas, V.*, Lo Celso, C.*, Giangreco, A., Ofstad, T., Prowse, D.M., Braun, K.M. and Watt, F.M. b-catenin and Hedgehog signal strength specifies number and location of hair follicles in adult epidermis without recruitment of bulge stem cells.   Dev. Cell.  9(1), 121-131.

Braun, K.M., Niemann, C., Jensen, U.B., Sundberg, J.P., Silva-Vargas, V. and Watt, F.M.  Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis.  2003.  Development.  130(21), 5241- 5255.

Braun, K.M., Degen, J.L. and Sandgren, E.P.  Hepatocyte transplantation in a model of toxin-induced liver disease: variable therapeutic effect during replacement of damaged parenchyma by donor cells.  2000.  Nat. Med.  6(3), 320-326.


View all Kristin Braun's Research Publications at: http://www.researchpublications.qmul.ac.uk

Teaching

Postgraduate

Course Director, MSc Regenerative Medicine

Module Lead/Course Lecturer: ICM7142 Stem cell and developmental biology

Module Lead/Course Lecturer:  ICM7144 Tissue-specific stem cells

Joint Module Lead:  ICM7146 Research project in regenerative medicine

Personal tutor, MSc Regenerative Medicine

 

Undergraduate and Intercalated

Joint Module Lead/Course Lecturer:  MBBS Part 1 Human Development

Joint Module Lead/Course Lecturer:  MBBS Part 2 Human Development

Joint Module Lead/Course Lecturer:  MBBS GEP Human Development

Senior Internal Examiner, MBBS Part 2 (Paper Bii)

Personal Mentor, MBBS Part 1 and Part 2

Facilitator, MBBS Problem based learning

Tutor, Student Selected Components (SSC2; SSC4)

Supervisor, BmedSci and BSc research projects

 

PhD Student Supervision

Current              Mr. Christopher Smith                    Primary Supervisor

Current              Mr. Sreekanth Reddy                     Secondary Supervisor

2014                 PhD (London), Supatra Marsh       Secondary Supervisor

2011                  PhD (London), Alex K. Elder          Primary Supervisor


Further information

  • The Royal Society Biological Sciences Board, Member
  • External examiner (PhD and MSc Vivas)
  • STEMnet Ambassador (http://www.stemnet.org.uk)
  • British Society for Cell Biology
  • International Society for Stem Cell Research
  • British Society for Investigative Dermatology
  • MBBS Junior Student-staff Liaison Committee
  • SMD Medical Assessment Sub-committee
  • Human Development Medical Education Committee

Contact

Centre for Cell Biology and Cutaneous Research
Blizard Institute
Barts and The London School of Medicine and Dentistry
Blizard Building
4 Newark Street
London
E1 2AT

+44 (0)20 7882 2350
This email address is being protected from spambots. You need JavaScript enabled to view it.