John Connelly

John Connelly

Ph.D.
Senior Lecturer

My laboratory is interested in how keratinocytes sense and respond to changes in their physical microenvironment. We employ engineered materials and model systems to precisely control the signals presented to cells.
Key projects include:
(1) The role of biophysical cues in epidermal fate decisions.
(2) The influence of substrate mechanics and topography on wound healing.
(3) Transcriptional regulators of mechano-transduction in keratinocytes.
We also have an on-going interest in tissue engineering and regenerative medicine, and a long-term goal for our research is to translate our findings into effective strategies for skin repair.

Bio

I received my Ph.D. in Bioengineering from the Georgia Institute of Technology where I investigated the chondrogenesis of mesenchymal progenitors within engineered hydrogels. I then did my postdoc in Professor Fiona Watt’s laboratory at the University of Cambridge where I developed micro-patterned substrates to study the roles of cell shape and the actin cytoskeleton in keratinocyte terminal differentiation. I joined the Centre for Cutaneous Research at Queen Mary in 2010 as a non-clinical lecturer.

Research

My laboratory is interested in how keratinocytes sense and respond to changes in their physical microenvironment.  We employ engineered materials and model systems to precisely control the signals presented to cells.  Key projects include: (1) The role of biophysical cues in epidermal fate decisions.  (2) The influence of substrate mechanics and topography on wound healing. (3) Transcriptional regulators of mechano-transduction in keratinocytes.  We also have an on-going interest in tissue engineering and regenerative medicine, and a long-term goal for our research is to translate our findings into effective strategies for skin repair.

Group Members

Dr. Patricia Costa, Post-doc

Dr. Roanne Jones, Post-doc

Miss Fiona Kenny, PhD student

Mr Georgios Theocharidis, PhD student

Mr Filipe Almeida, PhD student

Publications

Costa P, Gautrot JE, Connelly JT. “Directing cell migration using micro-patterned and dynamically adhesive polymer brushes” Acta Biomaterialia, 2014; 10(6): 2415-22. 

Trappmann B, Gautrot JE, Connelly JT, Strange DG, Li Y, Oyen ML, Cohen Stuart MA, Boehm H, Li B, Vogel V, Spatz JP, Watt FM, Huck WT. “Extracellular-matrix tethering regulates stem-cell fate” Nature Materials, 2012; 11(7): 642-9.

Connelly JT, Mishra A, Gautrot JE, Watt FM. “Shape-induced terminal differentiation of human epidermal stem cells requires p38 and is regulated by histone acetylation” PLoS One, 2011; 6(11): e27259.

Connelly JT, Gautrot JE, Trappmann B, Tan DW, Huck WTS, Watt FM.  “Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions” Nature Cell Biology, 2010; 12(7):711-8.

Connelly JT, Garcia AJ, Levenston ME.  "Inhibition of in vitro chondrogenesis in RGD-modified three dimensional alginate gels.” Biomaterials. 2007; 28(6):1071-83.


View all John Connelly's Research Publications at: http://www.researchpublications.qmul.ac.uk

Teaching

Course director MSc Regenerative Medicine

Module Lead ICM7143: Biomaterials in Regenerative Medicine

Module Lead ICMM132: Research Skills and Methodology

Problem Based Learning


Further information

Member of European Society for Biomaterials and British Society of Cell Biology
Journal Editor for Scientific Reports

July 2011: obtained BBSRC New Investigator Award

Contact

Centre for Cutaneous Research
Blizard Institute
Barts and The London School of Medicine and Dentistry
Blizard Building
4 Newark Street
London
E1 2AT

+44 (0)207 882 7160
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