David Leslie

David Leslie

Professor of Diabetes and Autoimmunity / Centre Lead

Professor David Leslie is consultant physician at St Bartholomew's Hospital and Professor of Diabetes and Autoimmunity at the Blizard Institute, Queen Mary, University of London. He was recently elected President of The Association of Physicians of Great Britian and Ireland.

He qualified and trained at Imperial College and subsequently at King's College Hospital and Royal Victoria Infirmary, Newcastle. He was an MRC Travelling Fellow at the University of Chicago, USA, and Welcome Trust Senior Clincal Research Fellow at both King's College and Charing Cross and Westminster Medical Schools.

He has an interest in the cause of autoimmune diabetes through the study of twins and disease syndromes.


David Leslie is the Reviews Editor of Diabetic Medicine and was on the Editorial Board of several major Journals. He gave a Royal College of Physicians Lecture in 2005, was made Honorary Professor of Central South University, China; is Director of the European Consortium Action LADA, Director of the British Diabetic Twin Trust, a member of the NIH Advisory Board on the Prevention of Diabetes, and is a Trustee of the British Twin Trust and the Muirhead Trust


His research involves studies using major patient resources (such as patients with adult-onset autoimmune disease and twins with diabetes), allied to cell and molecular studies including collaborations with the Human Epigenome Consortium and the NIH in America. Recent studies have lead to identification of a genetic component to protein glycation and the characterisation of latent onset diabetes of the adults following a major multi-million pound EU grant. Other studies include the development of novel vaccination-type therapies to limit the disease process in type 1 diabetes. Current research focuses on the epigenetics of type 1 diabetes funded by several sources including a major EUFP7 grant as part of the Blueprint Consortium.


Xiang Y, Zhou P, Li X, Huang G  et al. Heterogeneity of altered cytokine levels across the clinical spectrum of diabetes in china. Diabetes Care 34:1639-41 (2011).

Pham MN, Hawa MI, Pfleger C   et al. Pro- and anti-inflammatory cytokines in latent autoimmune diabetes in adults, type 1 and type 2 diabetes patients: Action LADA 4. Diabetologia 54:1630-8 (2011).

Pozzilli P, Leslie RD, Chan J, De Fronzo R, Monnier L, Raz I, Del Prato S. The A1C and ABCD of glycaemia management in type 2 diabetes: a physician's personalized approach. Diabetes Metab Res Rev 26:239-44 (2010).

Michaelides M, Kaines A, Hamilton RD et al. A prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (BOLT study) 12-month data: report 2. Ophthalmology 117:1078-1086 (2010).

Beyan H, Drexhage RC, van der Heul Nieuwenhuijsen L et al. Monocyte gene-expression profiles associated with childhood-onset type 1 diabetes and disease risk: a study of identical twins. Diabetes 59:1751-1755 (2010).

Leslie RD. Predicting adult-onset autoimmune diabetes: clarity from complexity. Diabetes 59: 330-331(2010).

Rakyan VK, Down TA, Maslau S et al. Aging-associated DNA hypermethylation occurs predominantly at Bivalent Chromatin Domains. Genome Res. 20: 434-439 (2010).

Allen JS, Pang K, Skowera A et al. Plasmacytoid dendritic cells are proportionally expanded at diagnosis of type 1 diabetes and enhance islet autoantigen presentation to T-cells through immune complex capture. Diabetes 58:138-145 (2009).

Hawa MI, Thivolet C, Mauricio D et al. Metabolic syndrome and autoimmune diabetes: Action LADA 3. Action LADA Group. Diabetes Care 32:160-164 (2009).

Beyan H, Leslie RDG. Autoimmune Diseases in Endocrinology. Type 1 diabetes. Ed. Weetman AP. Humana Press (2008).

Padmos RC, Schloot NC, Beyan H et al. Distinct monocyte gene-expression profiles in autoimmune diabetes. Diabetes 57:2768-7 (2008).

View all David Leslie's Research Publications at: http://www.researchpublications.qmul.ac.uk


Lisa Buckley
Huriya Beyan

Further information

Annual Barts Symposium
We are seeking Identical Twins discordant for Diabetes throughout UK


Centre for Diabetes
Blizard Institute
Barts and The London School of Medicine and Dentistry
Blizard Building 
4 Newark Street
E1 2AT

Administrator: Stephanie Cunningham
020 7882 2482
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020 7882 2358
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