Klaus Schmierer

Title: Dr
MB BS, PhD, FRCP
Reader in Clinical Neurology

Klaus Schmierer moved to Barts and The London School of Medicine & Dentistry in October 2009 following award of a Clinical Senior Lectureship by the Higher Education Funding Council for England (HEFCE).  After undergraduate studies at the Free University Berlin and the Hebrew University Jerusalem he received his training in neurology at the Charité, Humboldt University Berlin, between 1996 and 2001.  He then moved to London to pursue a career in academic neurology.

Research

Klaus Schmierer has a special interest in demyelinating diseases of the central nervous system, particularly multiple sclerosis (MS).  His team are keen to better understand the pathogenesis of MS, particularly the development of chronic disease progression, which is still poorly understood.  A major focus of their work is the relationship between myelin and neuro-axonal pathology, and changes affecting the cortical grey matter in MS.  Further interests include atypical manifestations of demyelination, gene expression in MS, and clinical trials.

Recent and ongoing research projects

  • Quantifying the pathology of multiple sclerosis to understand mechanisms underlying disease progression (using MRI and histopathology)
  • A phase II trial of Phenytoin for optic neuritis
  • MRI markers of grey matter pathology in MS
  • Development of a clinical and research database for people with MS

Publications

Petzold A, Tozer DJ, Schmierer K.  Axonal damage in the making: neurofilament phosphorylation, proton mobility and magnetisation transfer in multiple sclerosis normal appearing white matter. Exp Neurol 2011, in press.

Doepp F, Paul F, Valdueza JM, Schmierer K*, Schreiber SJ*.  No cerebro-cervical venous congestion in patients with multiple sclerosis. Ann Neurol 2010;68:173-83.

Schmierer K, Parkes HG, So P-W, An SF, Brandner SA, Ordidge RJ, Yousry TA, Miller DH. High field (9.4 Tesla) magnetic resonance imaging of multiple sclerosis cortical grey matter lesions. Brain 2010;133:858-67

Schmierer K, Scaravilli F, Altmann DR, Barker GJ, Miller DH. Magnetization transfer ratio and myelin in postmortem multiple sclerosis brain. Ann Neurol 2004;56:407-415.


View all Klaus Schmierer's Research Publications at: http://www.researchpublications.qmul.ac.uk

Teaching

Lecturer 
MSc  in Neuroscience and Translational Medicine
MBBS YEAR 1
SSC Neuroinflammation & MS for years 1, 2, 4 and 5
PBL facilitator.

Topics for PhD supervision

Quantifying the pathology of multiple sclerosis to understand mechanisms underlying disease progression (using MRI and histopathology)


Contact

Centre for Neuroscience and Trauma
Blizard Institute
Abernethy Building Room 2.05
Barts and The London School of Medicine and Dentistry
4 Newark Street, London
E1 2AT

020 7882 6246
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