Qualified at the Royal London Hospital Medical College in 1984 and, following House appointments, was awarded an MRC Training Fellowship in 1988, a MRC Fellowship in 1990 and Wellcome Trust Advanced Research Training Fellowship in 1991. Appointed Clinical Senior Lecturer/Consultant Histopathologist in 1996 and subsequently, Professor of Neuropathology. Clinical Director of Diagnostics and Therapeutics Directorate for Barts & The London NHS Trust. I have been appointed Honorary Lecturer in Healthcare Management, Keele University . I have a longstanding interest in the cellular processes leading to neurodegeneration, particularly of the motor system.